Evidence

The MHRA has withdrawn the UK licence for the IXCHIQ chikungunya vaccine

Sixteen months after it reached the UK market, the live chikungunya vaccine has been withdrawn.

Once-weekly basal insulin now has a UK licence and a NICE recommendation

For someone who needs help with every basal insulin dose, this means 52 assisted injections a year instead of 365.

A review of 27 systematic reviews shows which non-antibiotic options can help prevent recurrent UTI

Recurrent UTI drives a large share of antibiotic use in women. The alternatives vary a lot in how much evidence backs them.

The first dedicated trial of aspirin to prevent heart attack and stroke in CKD has reported

The trial aimed to recruit more than 25,000 people. The pandemic left it with 4,633. That limits how much its results can tell us.

The NHS-Galleri blood test found cancers but did not reduce late-stage diagnoses

Finding a cancer and changing its outcome are not the same thing. The largest trial of a multicancer blood test shows why.

Menopause is everywhere. But is everyone being heard?

Menopause awareness is growing, but inequities in access, symptom burden and clinician confidence may leave some women unheard.

Can digital care close the GLP-1 treatment gap?

A UK observational study of more than 8,000 women found substantial six-month weight loss and high retention in a structured digital-first GLP-1 programme. It is promising implementation evidence, but not a comparison with NHS or face-to-face care.

Metabolic Health Beyond BMI: What I Actually Measure in Primary Care

Dr Saira Bano explains why BMI is a starting point—not the whole assessment—and how waist-to-height ratio, HbA1c, blood pressure, lipids and cardiovascular risk help build a clearer metabolic picture in primary care.

Pregnancy complications still matter for heart and kidney health years later

A study of 1.4 million women in England shows that pregnancy records should be part of heart health discussions, not just antenatal notes.

Attending an NHS Health Check was associated with lower mortality

A London study of nearly 159,000 patients indicates the programme might do more than just spot high blood pressure early.

Iatrogenic menopause is associated with a higher risk of cardiovascular disease and mortality

Iatrogenic menopause is associated with a higher risk of cardiovascular disease, while menopause before 45 is associated with higher cardiovascular and all-cause mortality.

The changing outlook for children with psychiatric disorders

Children who met criteria for a psychiatric disorder in 2017 were more likely to see difficulties worsen over three years than earlier cohorts. A new England study underlines the importance of prevention, early identification and effective support.

Beyond the 10-Minute Limit: 4 Actionable Lifestyle Medicine Interventions for Primary Care

NICE backs a saliva test for endometriosis in revised draft guidance. What does the evidence show?

97.3% sensitivity, 94.1% specificity, and NICE still calls its accuracy in primary care unclear. Here is why both things are true.

Could your repeat PPI list become a Barrett’s screening list?

Three practices searched their records for patients on long-term PPIs and invited them for a capsule sponge test. Nearly 9 in 10 eligible, interested patients took it. About 1 in 25 had Barrett’s oesophagus.

Clinical trials in general practice: answering the safety question

Dr Fatima Tahir explains the safeguards that underpin clinical trials in general practice, from ethical review and informed consent to Good Clinical Practice and ongoing safety monitoring.

GLP-1 receptor agonists and obstructive sleep apnoea: what this study means for primary care

A large US matched cohort found lower recorded cerebrovascular, hospital-use and mortality outcomes among people with OSA exposed to GLP-1 receptor agonists. The finding is promising, but observational and not a replacement for standard OSA care.

LatAm-FINGERS: Can lifestyle intervention help prevent dementia?

Does chronic GLP-1 receptor agonist exposure remodel the pancreas? What the evidence actually shows

Preclinical studies show sustained molecular responses to GLP-1 receptor stimulation in pancreatic cell models. What does that mean for primary care, and what does it not show?

Bariatric surgery versus GLP-1RAs: which delivers better CV outcomes in obesity?

NG28 was the biggest NICE change in a decade. Here is what else moved this year.

The February 2026 NG28 update rewrote type 2 diabetes care for UK GPs. What changed, why it matters, and the four other NICE updates from the past year worth knowing.

The Change We Forgot to Finish Talking About

This is a chance for women to get their mojo back.

How to Get Started in Research as a Primary Care Professional in the UK

What your heart failure register is not telling you

Coding, registers and the four pillars in UK primary care